What is the average life expectancy for an individual with Morquio syndrome?

Unlike in several other MPS diseases, intellectual abilities are usually spared. Morquio syndrome includes mild, moderate, and severe forms. Although all forms are characterized by skeletal disease, individuals affected by milder cases may live over 70 years, while severe cases do not typically live beyond age 30.

What percentage of the population has Morquio syndrome?

Morquio syndrome is a rare inherited birth defect that is estimated to occur in one of every 200,000 births.

Can people die from Morquio syndrome?

Individuals with untreated severe Morquio A syndrome die of respiratory obstruction, cervical spinal cord complications, or heart valve disease in their second or third decade of life. The lifespan of individuals with the attenuated form of Morquio A syndrome has been noted to be as long as 70 years.

How many people in the US have Morquio syndrome?

It’s unknown how many people are affected by MPS IV. Some estimates place the rate at about 1 in 210,000 people, according to a case report in the journal Joint Bone Spine. The prevalence of the disorder also varies greatly by population.

What does Morquio syndrome do to your body?

The problems tied to Morquio syndrome lead to symptoms such as curved spine (scoliosis), joints that move more than they should (hypermobility), neck that moves more than it should (instability), a large head, short stature, wide teeth, heart and vision problems and a number of other complications.

What is the life expectancy of someone with Morquio syndrome?

Morquio Syndrome Life Expectancy. Individuals with Morqui Syndrome have a life expectancy of approximately 30 years. Some dies as early as age of 2 or 3 years old and some survive up to sixty years old. Early detection and intervention can prolong and enhance life.

What are the symptoms of Morquio neck syndrome?

Morquio Syndrome patient also has symptoms of atlanto-axial instability where the ligaments holding the first two vertebrae on the neck become very lax and the head is also very large in size (macrocephaly). The patient’s height is also below average for his/her age with short stature and specifically a short trunk.

Is there an international registry for Morquio syndrome?

The international registry for Morquio A was started by The International Morquio Organization and The Carol Ann Foundation. It is an excellent source of information regarding clinical manifestations and outcomes of patients with Morquio’s syndrome type A.

Are there any physical treatments for Morquio syndrome?

As of the present, there is still no specific treatment. Physical presentations are treated specifically. Osteotomies are done to correct the alignment of legs to improve gait. Spinal fusion is also considered to prevent progression of spinal deformities, spinal cord damage and death.

Morquio Syndrome Life Expectancy. Individuals with Morqui Syndrome have a life expectancy of approximately 30 years. Some dies as early as age of 2 or 3 years old and some survive up to sixty years old. Early detection and intervention can prolong and enhance life.

Are there any support groups for Morquio syndrome?

Furthermore, support groups, such as The National MPS Society, can foster community and help raise awareness about the condition. 3  Genetic conditions are always challenging. Since there is as yet no complete cure for Morquio syndrome—and since it’s a progressive condition—facing the disease can be very daunting.

How many copies of the Morquio gene are needed?

This disease is what’s called an autosomal recessive disorder, meaning that two copies of the abnormal gene are needed: one from each parent. Those who have only one such gene are carriers of Morquio syndrome and will not display symptoms. If both parents have this abnormality, the chance of the child having the condition is 25 percent. 2 

Who was the first person to discover Morquio syndrome?

The condition was first described, simultaneously and independently, in 1929, by Luis Morquio (1867–1935), a prominent Uruguayan physician who discovered it in Montevideo, and James Frederick Brailsford (1888–1961), an English radiologist in Birmingham, England.