How does a person inherit Marfan syndrome?
Marfan syndrome is inherited as an autosomal dominant trait, meaning that only one abnormal copy of the Marfan gene inherited from one parent is sufficient to have the condition. Defects or deletions (pathogenic variants) of the fibrillin-1 (FBN1) gene have been shown to cause Marfan syndrome.
Should I have children if I have Marfan syndrome?
Pregnancy creates extra stress on the heart and blood vessels. The biggest concern for patients with Marfan syndrome is serious complications of the aorta, such as a tear or rupture that can cause death or serious injury to both you and your unborn baby. The risk is greatest if your aorta is dilated more than 4 cm.
Does Marfan syndrome affect teeth?
Many people with Marfan syndrome have narrow jaws and a high-arched palate, which can create dental (tooth) and orthodontic (alignment) problems.
Why do people with Marfan syndrome have crowded teeth?
It may be concluded that the mutation associated with MFS does not predispose the periodontal ligament to a higher susceptibility to periodontitis. Further, crowded teeth may be the reason for a slight tendency towards more periodontal inflammation in Marfan patients.
What kind of syndrome is Marden Walker syndrome?
MWS is a heterogeneous, initially described as a syndrome. But this condition is more on the lines of a phenotypic expression of various heterogeneous diseases and belongs to the second group in the classification of arthrogryposis.
How does Marfan syndrome affect the human body?
Marfan syndrome is a disorder of the body’s connective tissues, a group of tissues that maintain the structure of the body and support internal organs and other tissues. Children usually inherit the disorder from one of their parents. Some people are only mildly affected by Marfan syndrome, while others develop more serious symptoms.
Are there any diagnostic tests for Marfan syndrome?
Other diagnostic tests for Marfan syndrome include a slit lamp eye exam in which the doctor will check for dislocated lenses. Note: Marfan syndrome is not the only genetic disorder that affects connective tissue.
Can a person with Marfan syndrome have Ehlers Danlos syndrome?
Note: Marfan syndrome is not the only genetic disorder that affects connective tissue. If a person doesn’t meet the criteria for Marfan, he or she may have Ehlers-Danlos syndrome, Loeys-Dietz syndrome, MASS phenotype, familial aortic aneurysm, and Sticklers syndrome. How Is Marfan Syndrome Treated?
MWS is a heterogeneous, initially described as a syndrome. But this condition is more on the lines of a phenotypic expression of various heterogeneous diseases and belongs to the second group in the classification of arthrogryposis.
What are the symptoms and causes of Marfan syndrome?
Marfan syndrome 1 Overview. Marfan syndrome is an inherited disorder that affects connective tissue — the fibers… 2 Symptoms. The signs and symptoms of Marfan syndrome vary greatly,… 3 Causes. Marfan syndrome is caused by a defect in the gene that enables your body to produce… 4 Risk factors. Marfan syndrome affects men and women equally…
Note: Marfan syndrome is not the only genetic disorder that affects connective tissue. If a person doesn’t meet the criteria for Marfan, he or she may have Ehlers-Danlos syndrome, Loeys-Dietz syndrome, MASS phenotype, familial aortic aneurysm, and Sticklers syndrome. How Is Marfan Syndrome Treated?
Where does an aortic dissection occur in Marfan syndrome?
This can occur anywhere in your aorta. Having an aneurysm increases the risk of an aortic dissection — a tear in the lining of the aorta, shown in the image on the right. Lens dislocation. Lens dislocation Some people who have Marfan syndrome may experience the dislocation of the lens in their eye.