Which disorder is due to an increase amount of melanin pigment in the skin when there is increased production of melanin by the melanocytes?
We briefly review vitiligo as a representative of an acquired hypopigmentation disorder. Pigments that determine human skin colors include melanin, hemoglobin (red), hemosiderin (brown), carotene (yellow), and bilin (yellow).
What is polymyositis?
Polymyositis is a disease that causes muscles to become irritated and inflamed. The muscles eventually start to break down and become weak. The condition can affect muscles all over the body. This can make even simple movements difficult.
Do organs contain melanin?
The melanin pigment was present in all of the tissue layers of most organs, while the melanin pigment was found in only specific layers of some of the organs. However, in some tissue samples, such as those obtained from the liver, no accumulation of the melanin pigment was observed.
What condition is due to a deficiency or absence of melanin?
Vitiligo occurs when pigment-producing cells (melanocytes) die or stop producing melanin — the pigment that gives your skin, hair and eyes color. The involved patches of skin become lighter or white.
What are the 3 types of melanin?
In humans, melanin exists as three forms: eumelanin (which is subdivided further into black and brown forms), pheomelanin, and neuromelanin.
What vitamin helps produce melanin?
Vitamin A. Studies suggest vitamin A is important to melanin production and is essential to having healthy skin. You get vitamin A from the food you eat, especially vegetables that contain beta carotene, such as carrots, sweet potatoes, spinach, and peas.
What organs are affected by polymyositis?
Polymyositis mostly affects the muscles of the hips and thighs, the upper arms, the top part of the back, the shoulder area and the neck.
What can stop melanin production?
Sunscreen and sun exposure Sunscreen protects the skin from UV rays, which slow down your melanin production.
Can you have a melanin deficiency?
A deficiency in melanin can lead to several disorders and diseases. For example, a complete absence of melanin causes a condition called albinism. Melanin deficiency has previously been associated with various genetic abnormalities and congenital defects.
What race has most melanin?
Analysis of melanosome size revealed a significant and progressive variation in size with ethnicity: African skin having the largest melanosomes followed in turn by Indian, Mexican, Chinese and European.
Where are the hyperpigmentation lesions located in black neonates?
TPM was originally described to be more frequent in black neonates when residual hyperpigmentation was included in its definition. The eruption is always present at birth. Lesions are located on the chin, neck, nape, upper chest, lower back, and buttocks, and also on the lower abdomen and medial side of the thighs.
What kind of skin disease makes your skin turn blue?
Argyria is a rare skin disorder that causes the skin to change color into a blue or grayish hue.
Why do some people have trouble with their skin color?
Troubles in skin color may raise considerable concern in black and Asian communities. Normal constitutive pigmentation is under the control of myriad genes, but recent studies in humans have attributed a major part of pigmentation variation across races to a limited number of genes.
What kind of acanthosis is associated with hyperpigmentation?
Moderate acanthosis can be associated with this condition. In the dermis, eosinophils and neutrophils may be seen around capillaries and the upper portion of the hair follicle. TPM was originally described to be more frequent in black neonates when residual hyperpigmentation was included in its definition. The eruption is always present at birth.