What portion of human population is affected by Fragile X?
Conservative estimates report that fragile X syndrome affects approximately 1 in 2500-4000 males and 1 in 7000-8000 females. The prevalence of female carrier status has been estimated to be as high as 1 in 130-250 population; the prevalence of male carrier status is estimated to be 1 in 250-800 population.
Does fragile X affect a certain ethnic group?
This study identified statistically significant differences in fragile X premutation allele frequency among some of the ethnic groups. However, when comparing individual groups to the overall pan-ethnic frequency, the only group remaining significantly different was the Asian group.
Why are males more affected by fragile X syndrome?
Symptoms of Fragile-X syndrome are more severe in males compared with females. Because females have two X chromosomes, an inherited damaged FMR1 gene can be compensated for by an inherited healthy FMR1 gene. Unlike females, males only have one X chromosome, so an inherited damaged copy is their only copy.
How many people are diagnosed with Fragile X syndrome?
. 1 FXS affects both males and females. Females often have milder symptoms than males. 2 The exact number of people who have FXS is unknown, but a review of research studies estimated that about 1 in 7,000 males and about 1 in 11,000 females have been diagnosed with FXS. 3
What can I do about fragile X syndrome?
Fragile X-associated Tremor/Ataxia Syndrome: Who, What, When, How? The NFXF Community Support Network brings families together for support, education, and fun.
Who are the people with Fragile X Tremor syndrome?
Fragile X tremor-ataxia syndrome (FXTAS) is characterized by a progressive adult-onset movement abnormalities (ataxia) and rhythmic, involuntary movements (tremors) that affect mostly men. Individuals with this condition have a premutation in the FMR1 gene (55-200 CGG repeats).
Can you get pregnant with Fragile X syndrome?
Maybe you or a family member found out they are a Fragile X carrier and are trying to get pregnant, or you might be pregnant and have found out that your baby may have Fragile X syndrome. Whatever the case, we know you have a lot of questions, worries, anxieties, etc.
What is the life expectancy of Fragile X syndrome?
Life expectancy for people with fragile X syndrome is generally normal. Many affected people participate in an active lifestyle and have good health.
How do I know if I have fragile X syndrome?
There are very few outward signs of fragile X syndrome in babies, but one is a tendency to have a large head circumference. An experienced geneticist may note subtle differences in facial characteristics. Intellectual disability is the hallmark of this condition and, in females, this may be the only sign of the problem.
What are the main causes of Fragile X syndrome?
Fragile X syndrome is a genetic disorder caused by a change to one of the genes on the X chromosome . It is the most common inherited cause of intellectual disability and the most common single gene cause of autism.
How many people get fragile X syndrome each year?
Fragile X syndrome is the most common inherited cause of learning problems and intellectual disabilities. In the United States, about 1 in 4,000 boys and 1 in 8,000 girls are born each year with fragile X. Usually, boys with fragile X have more serious learning and behavior problems than girls.