What is the phenotype and genotype of sickle cell trait?
Any combination of two of these alleles represents an individual’s genotype. Individuals with genotype AS have the sickle cell trait phenotype, and individuals with SS genotype have the sickle cell disease phenotype.
How is the genotype of sickle cell disease determined?
Sickle cell disease: Know your genotype. The experts say the different forms of sickle cell disease are determined by the genes inherited from the person’s parents. Someone who inherits a sickle cell gene from each parent has haemoglobin SS disease, also called sickle cell anaemia.
Can a person with sickle cell trait have more than one allele?
[edit on Wikidata] Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle-cell disease that occur in a person who has two copies of that allele (is homozygous).
Is the sickle cell trait a benign condition?
Sickle cell trait is a hemoglobin genotype AS and is generally regarded as a benign condition. However, individuals with sickle cell trait may have rare complications.
Which is better sickle cell trait or hemoglobin?
Sickle cell trait provides a survival advantage over people with normal hemoglobin in regions where malaria is endemic.
How does a person get sickle cell trait?
It is inherited when a child receives two sickle cell genes—one from each parent. A person with SCD can pass the disease or SCT on to his or her children. How Does Someone Get Sickle Cell Trait? People who have inherited one sickle cell gene and one normal gene have SCT.
What are the phenotypes of sickle cell disease?
The following pedigree traces sickle cell disease through four generations of a family living in the highlands of eastern Africa. Genotypes are: H = normal hemoglobin; h = sickling hemoglobin; phenotypes are: HH = normal; Hh = sickle cell trait and hh = sickle cell anemia.
Can a person with sickle cell trait have SCD?
People who inherit one sickle cell gene and one normal gene have sickle cell trait (SCT). People with SCT usually do not have any of the symptoms of sickle cell disease (SCD), but they can pass the trait on to their children. How Sickle Cell Trait is Inherited
How many sickle cell haplotypes are there in the world?
Sickle cell variants descended from this ancestral haplotype comprise five haplotypes named after toponyms or ethnolinguistic groups (the Arabian/Indian, Benin, Cameroon, Central African Republic/Bantu, and Senegal variants), and another designation earmarked for atypical sickle-cell haplotypes.