What is the hypothesis in this article about how cystic fibrosis is related to cholera?

What is the hypothesis in this article about how cystic fibrosis is related to cholera?

A researcher from the Faculty of Medicine, Shiraz University of Medical Sciences, in Iran, has suggested the unconventional idea that people with cystic fibrosis (CF) could be more resilient to cholera and, vice versa, that people who contract cholera could develop resistance to cystic fibrosis.

What group of diseases does cystic fibrosis belong to?

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections.

What other health conditions are connected to cystic fibrosis?

CF causes thick mucus that clogs certain organs, such as the lungs, pancreas, and intestines. This may cause malnutrition, poor growth, frequent respiratory infections, breathing problems, and chronic lung disease.

How does cystic fibrosis affect the intestine?

The presentation begins with a discussion of the involvement of cystic fibrosis (CF) transmembrane conductance regulators (CFTR) transport in the intestine and how cholera affects intestinal transport and is then extended to CFTR transport in various organ systems in CF.

How does cholera affect the transport of CFTR?

The article follows our normal presentation which begins with a discussion of the involvement of CFTR transport in the intestine and how cholera affects intestinal transport, extends to CFTR transport in various organ systems in CF, and concludes with the logic behind many of the treatments that improve CF.

What are the messengers of cystic fibrosis ( CF )?

The second messengers Ca 2+ and cAMP are the links between the membrane receptors on the basolateral side and the effects on transport on the apical side of these cells. CFTR, cystic fibrosis (CF) transmembrane conductance regulators. (Modeled after figures in Ref. 15 .)

How does cholera toxin cause loss of body fluid?

How does cholera toxin cause loss of body fluid? Cholera toxin has binding and enzymatically active subunits that activate the adenylate cyclase system of cells in the intestinal mucosa leading to increased levels of intracellular cAMP ( 11 ).

What treatments are available to CF patients?

The methods used in treating cystic fibrosis include medications such as antibiotics, anti-inflammatory drugs, inhaled bronchodilators, oral pancreatic enzymes, and mucus-thinning medications. In addition physical therapy, pulmonary rehabilitation, and surgical procedures can be required.

What is new CF drug?

Last Updated: October 23, 2019. Trikafta combines the drugs elexacaftor, tezacaftor, and ivacaftor. A new drug that can treat approximately 9 out of 10 people living with the life-threatening chronic genetic disorder cystic fibrosis (CF) has been approved by the U.S. Food and Drug Administration (FDA). Oct 23 2019

What is CF drug?

Kalydeco, the drug that treats the cause of cystic fibrosis , not just symptoms. People with cystic fibrosis, Australia’s most common inherited condition, have thick mucus, including on the lungs. Kalydeco (ivacaftor) is a drug used to treat cystic fibrosis, a disorder that affects many organs, particularly the lungs.

What is the genotype of cystic fibrosis?

The genotype of people with cystic fibrosis is homozygous recessive. In other words, they carry two copies of the non-functioning allele for the gene that creates specific ion-channels. Some people, known as “carriers” can have a functioning, normal phenotype, while having a heterozygous genotype.