What is the half life of Depo Provera?
Using an unextracted radioimmunoassay procedure for the assay of medroxyprogesterone acetate in serum, the apparent half-life for medroxyprogesterone acetate following IM administration of DEPO-PROVERA Contraceptive Injection is approximately 50 days.
When to give the first injection of Depo-Provera?
It is recommended that the doctor uses these leaflets to aid counselling of the patient before giving the injection of Depo-Provera. First injection: To provide contraceptive cover in the first cycle of use, an injection of 150 mg i.m. should be given during the first five days of a normal menstrual cycle.
When to discontinue Depo Provera CI in adolescents?
After discontinuing Depo-Provera CI in these adolescents, mean BMD loss at the total hip and femoral neck did not fully recover by 5 years (60 months) post-treatment in the sub-group of adolescents who were treated for more than 2 years [see Clinical Studies (14.3) ].
When to stop taking Depo Provera for weight gain?
Sensible eating and frequent exercise may help to minimize weight gain while using this birth control method. You can stop using Depo Provera at any time by choosing not to have your next scheduled injection. It’s also suggested that you should stop Depo Provera use after you have been receiving injections for two years.
Using an unextracted radioimmunoassay procedure for the assay of medroxyprogesterone acetate in serum, the apparent half-life for medroxyprogesterone acetate following IM administration of DEPO-PROVERA Contraceptive Injection is approximately 50 days.
How old do you have to be to use Depo Provera?
The researchers also noted that 18-21 year old Depo-Provera users had much lower bone densities at the beginning of the study than did 18-21 year old non-users.
Is the bone loss from Depo Provera reversible?
Women who use Depo-Provera are at risk for loss of bone density, although this study provides evidence that Depo-Provera’s effects on bone density appear to be largely reversible.
When did Pfizer get approval for Depo Provera?
The original manufacturer, Upjohn, was repeatedly denied approval by the Food and Drug Administration in the 1970s, until 1992 when it was allowed to market Depo-Provera in the United States for contraception. According to Pfizer spokesman Rebecca Hamm, Depo-Provera has been studied in clinical trials up to seven years.