What is the effect of porphyria?

What is the effect of porphyria?

People who have acute porphyrias commonly suffer fatigue. This may be due to symptoms affecting muscles and joints (such as pain, numbness and weakness) and the sleep disturbance this may cause. In some cases the effects of medication used to control symptoms may contribute to bouts of tiredness.

Can porphyria go away?

Porphyria is usually inherited — one or both parents pass along an abnormal gene to their child. Although porphyria can’t be cured, certain lifestyle changes to avoid triggering symptoms may help you manage it. Treatment for symptoms depends on the type of porphyria you have.

What happens to your skin when you have porphyria?

Some types of porphyria, called cutaneous porphyrias, primarily affect the skin. Areas of skin exposed to the sun become fragile and blistered, which can lead to infection, scarring, changes in skin coloring (pigmentation), and increased hair growth.

What are the effects of high levels of porphyrins?

High levels of porphyrins can cause significant problems. There are two general categories of porphyria: acute, which mainly affects the nervous system, and cutaneous, which mainly affects the skin. Some types of porphyria have both nervous system symptoms and skin symptoms.

What kind of muscle weakness does porphyria cause?

Some types of acute porphyrias cause muscle weakness. Muscle problems can be life-threatening if weakness affects the muscles that make respiration (breathing) possible. Hospitalization is required if porphyria affects the respiratory muscles.

Where does heme production occur in porphyria disease?

Heme production, which occurs in the bone marrow and liver, involves eight different enzymes — a shortage (deficiency) of a specific enzyme determines the type of porphyria. In cutaneous porphyria, the porphyrins build up in the skin, and when exposed to sunlight, cause symptoms.

What are the signs and symptoms of porphyria?

People living with cutaneous types of porphyria, which affects the skin, often experience symptoms including: 1 Oversensitivity to sunlight. 2 Itching. 3 Swelling of skin exposed to sunlight. 4 Abrasions, blisters on the skin, skin erosions. 5 Scarring of sun exposed areas of the skin leading to fragile skin.

High levels of porphyrins can cause significant problems. There are two general categories of porphyria: acute, which mainly affects the nervous system, and cutaneous, which mainly affects the skin. Some types of porphyria have both nervous system symptoms and skin symptoms.

Can a cutaneous porphyria attack cause permanent damage?

Severe attacks of acute porphyria can sometimes cause nerve damage and muscle weakness that can take months to get better. Since cutaneous porphyria symptoms start when your skin is in sunlight, staying out of the sun will heal your skin and help prevent permanent damage.

Heme production, which occurs in the bone marrow and liver, involves eight different enzymes — a shortage (deficiency) of a specific enzyme determines the type of porphyria. In cutaneous porphyria, the porphyrins build up in the skin, and when exposed to sunlight, cause symptoms.