What is the difference between sickle cell anemia and sickle cell thalassemia?

What is the difference between sickle cell anemia and sickle cell thalassemia?

In sickle cell disease, an abnormal hemoglobin protein (i.e., hemoglobin S) is made, but it doesn’t function correctly; however, in beta thalassemia, the mutation in HBB results in less hemoglobin protein being made.

Is Sickle Cell Anemia a type of thalassemia?

Sickle beta thalassemia is an inherited condition that affects hemoglobin, the protein in red blood cells that carries oxygen to different parts of the body. It is a type of sickle cell disease.

What is the genetic defect in sickle cell anemia?

Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels.

Is there a genetic defect in sickle cell anemia?

Genetic defect in thalassemia does not provide a resistance against malaria. Sickle cell anemia is an autosomal recessive disorder. Thalassemia is an autosomal codominant disorder. Thalassemia and sickle cell anemia are two serious hematological disorders mostly encountered in the pediatric practice.

How is thalassemia related to sickle cell disease?

As with sickle cell disease, drugs that increase production of fetal hemoglobin can partially correct the anemia of thalassemia, but efforts to improve the treatment of thalassemia continue.

How is sickle cell anemia related to the HBB gene?

Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS.

What’s the difference between thalassemia trait and major?

When the words “trait,” “minor,” “intermedia,” or “major” are used, these words describe how severe the thalassemia is. A person who has thalassemia trait may not have any symptoms at all or may have only mild anemia, while a person with thalassemia major may have severe symptoms and may need regular blood transfusions.

Who are some famous people with sickle cell anemia?

A number of famous individuals have suffered from sickle cell anemia including Miles Davis, perhaps the most famous jazz musician to have lived (some consider his platinum-selling album Kind of Blue to be THE jazz album), and Tionne ‘T-Boz’ Watkins, a singer and founder of the R&B/hip-hop group TLC.

What are the statistics of sickle cell disease?

Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans. The disease is estimated to occur in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans.

What is sickle cell disease?

Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.