What is the advantage of having sickle cell anemia in Africa?

What is the advantage of having sickle cell anemia in Africa?

Although the sickle mutation at one allele of the beta-globin gene (heterozygosity) confers a survival advantage in malaria endemic areas, especially for children, inheritance of the mutation at both alleles (HbSS) predisposes individuals to severe malaria and increased malaria mortality, as well as increased mortality …

Why is sickle cell anemia actually advantageous in areas prone to malaria?

Carriers of the sickle cell trait (ie, heterozygotes who carry one HbS allele and one normal adult hemoglobin [HbA] allele) have some resistance to the often-fatal malaria caused by Plasmodium falciparum. This property explains the distribution and persistence of this gene in the population in malaria-endemic areas.

Is sickle cell good in Africa?

Sickle cell disease is an important but largely neglected risk to child survival in most African countries. Action is needed on at least two fronts.

What country has the most sickle cell disease?

Sickle Cell Disease (SCD), the most common blood disorder in the world, requires daily care and can cause major problems and long-term disability. Africa has the highest prevalence rates, with 20 – 30% in countries such as Nigeria, Cameroon, Republic of Congo, Gabon and Ghana.

Why are sickle cell anemia more common in Africa?

Sickle cell is found more frequently in persons of Middle Eastern, Indian, Mediterranean and African heritage because those geographic regions are most prone to malaria. The gene variant for sickle cell disease is related to malaria, not skin color. In the African population, the presence of sickle cell gene is an example of natural selection.

What kind of disease is sickle cell anaemia?

Sickle cell disease (SCD), or sickle cell anaemia, is a major genetic disease that affects most countries in the African Region. In sickle cell disease, the normal round shape of red blood cells become like crescent moons.

Is the sickle cell trait a survival advantage?

However, in areas such as the US, where malaria is not a problem, the trait no longer provides a survival advantage. Instead, it poses the threat of SCD, which occurs in children of carriers who inherit the sickle cell gene from both parents (ie, HbSS). Strouse J. Sickle cell disease. Handb Clin Neurol. 2016. 138:311-24. [Medline].

How are red blood cells affected by sickle cell disease?

Sickle-cell disease is a hereditary blood disorder in which the red blood cells (erythrocytes) can take on a rather unique shape. It takes two genes for the sickle-cell mutation (one from the father, one from the mother) for an individual to get sickle-cell disease.

What is the survival rate of sickle cell anemia?

The one-year overall survival rate was 100%, and disease-free survival rate was 78%. The study shows that UCBT is able to cure children with severe SCD, greatly reducing the incidence and severity of chronic GVHD.

What is the life expectancy of someone with sickle cell disease?

Those cells can cause blockages of blood to organs and tissues, debilitating pain, and life-threatening complications. People with sickle cell disease have an average life expectancy of 40 to 60 years.

Is it good to have sickle cell anemia?

People with sickle cell trait are generally healthy . Only rarely do people who have sickle cell trait have complications similar to those seen in people who have sickle cell disease. But people with sickle cell trait are carriers of a defective hemoglobin S gene, so they can pass it on when they have a child.

What is the life span of a sickle cell?

New and aggressive treatments for sickle cell disease are prolonging life and improving its quality. As recently as 1973, the average lifespan for people with sickle cell disease was only 14 years. Currently, life expectancy for these patients can reach 50 years and over.