What is lepromatous leprosy?
Lepromatous leprosy is a form of leprosy characterized by pale macules in the skin. It results from the failure of Th1 cell activation which is necessary to eradicate the mycobacteria (Th1 response is required to activate macrophages that engulf and contain the disease).
What is the difference between tuberculoid and lepromatous leprosy?
Leprosy has traditionally been classified into two major types, tuberculoid and lepromatous. Patients with tuberculoid leprosy have limited disease and relatively few bacteria in the skin and nerves, while lepromatous patients have widespread disease and large numbers of bacteria.
What is Tuberculoid leprosy?
Tuberculoid leprosy is a form of leprosy characterized by solitary skin lesions that are asymmetrically distributed with few lesions and well demarcated edges. There is also early and marked nerve damage.
What is the difference between Paucibacillary and Multibacillary leprosy?
Paucibacillary patients are those who are skin smear negative and show no evidence of more advanced disease on biopsy. Multibacillary patients are those who are skin smear positive and/or have a biopsy indicating more advanced disease.
What are the different types of leprosy symptoms?
1 In tuberculoid leprosy, the immune response is good. A person with this type of infection only exhibits a few lesions. 2 In lepromatous leprosy, the immune response is poor. This type also affects the skin, nerves, and other organs. 3 In borderline leprosy, there are clinical features of both tuberculoid and lepromatous leprosy. …
Is the lepromatous form of leprosy curable?
Contrary to popular belief, both forms of leprosy are curable, with the lepromatous form classically treated with antibiotics dapsone, rifampin and clofazimine for as long as 2–5 years, but if left untreated the person may die up to 20 or 30 years from its inception.
Which is more contagious borderline or lepromatous leprosy?
In lepromatous leprosy, the immune response is poor. This type also affects the skin, nerves, and other organs. There are widespread lesions, including nodules (large lumps and bumps). This form of disease is more contagious. In borderline leprosy, there are clinical features of both tuberculoid and lepromatous leprosy.
What’s the difference between tuberculous and lepromatous leprosy?
This early presentation is the same for both tuberculous and lepromatous forms of leprosy as they are a spectrum of the same disease (lepromatous being the more contagious and severe form in patients with impaired Th1 response). Disease progression is extremely slow, and signs of infection may not appear for years.
What’s the difference between leprosy and lepromatous disease?
Patients with tuberculoid leprosy have limited disease and relatively few bacteria in the skin and nerves, while lepromatous patients have widespread disease and large numbers of bacteria.
What happens if leprosy is left untreated?
Leprosy was once feared as a highly contagious and devastating disease, but now we know it doesn’t spread easily and treatment is very effective. However, if left untreated, the nerve damage can result in crippling of hands and feet, paralysis, and blindness. What is Hansen’s Disease?
What kind of leprosy has pale macules in the skin?
Lepromatous leprosy is a form of leprosy characterized by pale macules in the skin. It results from the failure of Th1 cell activation which is necessary to eradicate the mycobacteria (Th1 response is required to activate macrophages that engulf and contain the disease).
What kind of cells are found in nodular leprosy?
Ulcerated nodules contain large numbers of M. leprae acid-fast bacilli packed in macrophages that appear as large foamy cells. The face of this male patient exhibited some of the pathologic characteristic associated with a case of nodular lepromatous, or multibacillary (MB), Hansen’s disease.