What is clozapine prescribed for?
Clozapine is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Clozapine rebalances dopamine and serotonin to improve thinking, mood, and behavior.
What are the main side effects associated clozapine?
Clozapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness, feeling unsteady, or having trouble keeping your balance.
- increased salivation.
- dry mouth.
Does everyone gain weight on clozapine?
Significant weight gain occurs in about one third of patients who take clozapine, similar to some other antipsychotic medications. A 5- to 10-pound weight gain should lead to intervention.
How can I lose weight while taking clozapine?
The safest way for anyone to lose excess weight whether clozapine-related or not, is to use a combination of a low calorie diet accompanied by an increase in physical exercise. Referral to a dietician may be appropriate for some patients.
Are there any clinical practice guidelines for clozapine?
Studies of clozapine utilization have shown that adherence to guidelines has been poor through the years with clozapine been consistently underutilized in the US, UK, Canada, New Zealand and Australia [ 9, 21 – 26, 42 – 46 ].
Is there a risk of covid-19 in clozapine treated patients?
The agranulocytosis linked to clozapine is much less serious when compared to the mortality due to respiratory conditions. There is a high theoretical risk for Clozapine treated patients to catch COVID-19 and patients and carers should be on high alert in these critical periods; they should adhere to the preventive measures.
Is it safe to take clozapine with a high neutrophil count?
Neutrophil count — For all patients taking clozapine in the United States, the US Food and Drug Administration requires regular monitoring and registry reporting of neutrophil counts [ 1 ]. This process has been successful in allowing safe use of clozapine while avoiding deaths due to clozapine-induced agranulocytosis [ 10 ].
Is it possible to catch flu from clozapine?
It is a well-understood observation that patients treated with clozapine are highly vulnerable to influenza or its complications if they catch it, although the mechanism of such higher risk of infection is not clear.
Do you have to be a prescriber to prescribe clozapine?
Prescribers must be certified in the Clozapine REMS Program to prescribe clozapine. If you choose to allow designees to act on your behalf, each designee must be certified in the Clozapine REMS Program. For more information on the designee certification process, please go to Prescriber Designee Certification .
When do prescribers have to certify for clozapine Rems?
Prescribers are required to certify in the Clozapine REMS Program as soon as possible to continue patient therapy. If prescribers are not certified at the time of the 02/2019 Clozapine REMS Program Modification, a dispense of clozapine will not be authorized for patients under their care.
How to report an adverse event with clozapine?
Promptly report suspected adverse events associated with the use of a clozapine directly to the Clozapine REMS Program Contact Center at 844-267-8678. You should also report adverse event information to the FDA MedWatch Reporting System by telephone at (800) FDA-1088, by mail using Form 3500, or online.
How can I change the Monitoring frequency of clozapine?
Prescribers and prescriber designees can also modify a patient’s monitoring frequency by calling the Clozapine REMS Program Contact Center at 844-267-8678 or by faxing the update via the Clozapine REMS ANC Lab Reporting Form to the Clozapine REMS Program Contact Center for processing. Note: A pharmacy cannot update a patient’s monitoring frequency.