What does high direct bilirubin mean?

What does high direct bilirubin mean?

Elevated levels may indicate liver damage or disease. Higher than normal levels of direct bilirubin in your blood may indicate your liver isn’t clearing bilirubin properly. Elevated levels of indirect bilirubin may indicate other problems.

What is an abnormal direct bilirubin level?

Typically, bilirubin levels fall somewhere between 0.3 and 1.2 milligrams per deciliter (mg/dL). Anything above 1.2 mg/dL is usually considered high. The condition of having high bilirubin levels is called hyperbilirubinemia.

Is direct bilirubin 0.4 normal?

What are normal bilirubin levels in adults? Normal values of direct bilirubin range from 0 to 0.4 mg/dL. Total bilirubin (direct and indirect) range from about 0.2 to 1.2 mg/dL (some lab values range as high as 1.9 mg/dL).

How do you control high bilirubin?

Quick tips

  1. Drink at least eight glasses of fluids per day.
  2. Consider adding milk thistle to your routine.
  3. Opt for fruits like papaya and mango, which are rich in digestive enzymes.
  4. Eat at least 2 1/2 cups of veggies and 2 cups of fruit per day.
  5. Look for high-fiber foods, such as oatmeal, berries, and almonds.

How can I lower my bilirubin directly?

What’s the difference between total and direct bilirubin?

1 Bilirubin direct level is higher than the total bilirubin level, for instance; direct 1.0 and total 0.8 mg/dl. 2 Bilirubin levels show slight increase above the upper normal limit; for ex. Total 1.1 and 1.2 mg/dl. 3 Total bilirubin results are very low: 0, 0.1, 0.2, 0.3 mg/dl which could be false low results or wrong test.

When is indirect bilirubin too high in blood?

Indirect bilirubin may be too high when the liver is unable to adequately process (conjugated) bilirubin or when there is abnormal destruction of red blood cells (hemolysis). Meanwhile, direct bilirubin may be too high if the liver is unable to pass on the bilirubin after it has been conjugated. Want help making sense of your lab results?

What does a conjugated bilirubin test look for?

Conjugated bilirubin This test looks for bilirubin in your blood or urine. Bilirubin is a substance made when your body breaks down old red blood cells. This is a normal process. A small amount of bilirubin in your blood is normal. Healthy adults make 250 to 350 milligrams (mg) of bilirubin each day.

How does SLCO1B1 affect direct bilirubin levels?

Variations in SLCO1B1 affect the rate and efficiency of bilirubin conjugation and, therefore, influence your indirect bilirubin levels [ 38 ]. MRP2 is a gene that affects how well the liver excretes certain compounds such as direct bilirubin. Variations in this gene can reduce excretion and lead to higher direct bilirubin levels [ 38 ].

What’s the difference between indirect and direct bilirubin?

A bilirubin test measures total bilirubin. It can also give levels of two different types of bilirubin: unconjugated and conjugated. Unconjugated (“indirect”) bilirubin. This is the bilirubin created from red blood cell breakdown. It travels in the blood to the liver.

When does direct bilirubin cause jaundice in an adult?

Jaundice can occur in adults when bilirubin is higher than 2.3 mg/dL [ 37 ]. The UGT1A1 enzyme, which converts indirect bilirubin into direct bilirubin, is well-developed in the adult liver, but not in the livers of newborns.

What are the normal results for a bilirubin test?

Typically, you’ll get results for direct and total bilirubin. Normal results for a total bilirubin test are 1.2 milligrams per deciliter (mg/dL) for adults and usually 1 mg/dL for those under 18. Normal results for direct bilirubin are generally 0.3 mg/dL. These results may vary slightly from laboratory to laboratory.

What are the medical short codes for bilirubin?

Medical short codes for TSB, DSB, ISB are total, direct, indirect serum bilirubin respectively. Total bilirubin is the sum of all bilirubin forms in the blood, and not representing different type of bilirubin in the body.