What cells does hepatitis B target?

What cells does hepatitis B target?

Because hepatocytes are the major cell type in the liver, it might be expected that they would also be the major target of infection by a liver-tropic virus such as HBV. Indeed, this appears to be the case. Hepatocytes are the only confirmed site of replication for all members of this virus family.

How does hepatitis B enter the host cell?

Host Cell Factors Involved in HBV Internalization. After binding to the hepatocyte via NTCP, HBV must enter the cell. This entry is thought to occur via endocytosis.

What does hepatitis B do to your cells?

Necrosis (death) of liver cells, inflammation, and fibrosis that occur in chronic hepatitis may lead over time to liver failure. The hepatitis B vaccine is recommended for healthcare workers, people who live with someone with hepatitis B, and others at higher risk. The hepatitis B virus can damage liver cells.

How does hepatitis B affect the cells?

Hepatitis B is a viral infection that causes liver inflammation and damage. Inflammation is swelling that occurs when tissues of the body become injured or infected. Inflammation can damage organs. Viruses link invade normal cells in your body.

Which is the inner core of the hepatitis B virus?

The inner core of the virus is a protein shell referred to as the hepatitis B core antigen or “HBcAg,” which contains the hepatitis B virus DNA and enzymes used in viral replication. The hepatitis B virus (HBV) has a complex life cycle. The virus enters the host liver cell and is transported into the nucleus of the liver cell.

What is the life cycle of hepatitis B?

Life Cycle of the Hepatitis B Virus. The hepatitis B virus (HBV) has a complex life cycle. The virus enters the host liver cell and is transported into the nucleus of the liver cell.

Where does the HBV virus go after it leaves the liver?

New HBV virus is packaged and leaves the liver cell, with the stable viral cccDNA remaining in the nucleus where it can integrate into the DNA of the host liver cell, as well as continue to create new hepatitis B virus.

How does the HBV virus replicate in the host?

HBV replicates through an RNA intermediate and can integrate into the host genome. The unique features of the HBV replication cycle confer a distinct ability of the virus to persist in infected cells.

How does the hepatitis B virus get into the cell?

The life cycle of hepatitis B virus is complex. Hepatitis B is one of a few known pararetroviruses: non-retroviruses that still use reverse transcription in their replication process. The virus gains entry into the cell by binding to NTCP on the surface and being endocytosed.

Life Cycle of the Hepatitis B Virus. The hepatitis B virus (HBV) has a complex life cycle. The virus enters the host liver cell and is transported into the nucleus of the liver cell.

What does it mean if you have Hep B?

Thus, “hepatitis B” refers to inflammation of the liver caused by the hepatitis B virus. With early detection and appropriate follow-up medical care, people living with a chronic hepatitis B infection can expect to enjoy a long and healthy life.

HBV replicates through an RNA intermediate and can integrate into the host genome. The unique features of the HBV replication cycle confer a distinct ability of the virus to persist in infected cells.