What causes bilateral coloboma?

What causes bilateral coloboma?

Coloboma arises from abnormal development of the eye. During the second month of development before birth, a seam called the optic fissure (also known as the choroidal fissure or embryonic fissure) closes to form the structures of the eye. When the optic fissure does not close completely, the result is a coloboma.

What syndrome is associated with coloboma?

Treacher-Collins syndrome. Cat-eye syndrome where the coloboma is a vertical one in the iris, caused by an abnormality of chromosome 22q11.

What is a retinal coloboma?

Listen. Retinochoroidal coloboma is an eye abnormality that occurs before birth. It is characterized by missing pieces of tissue in both the retina (the light-sensitive tissue lining the back of the eye) and choroid (the blood vessel layer under the retina).

How do coloboma people see?

Coloboma can affect your iris, the tissue that gives you your eye colour. Your pupil may look oval if the coloboma is partial, but if more of your lower iris is missing, your pupil will look more keyhole shaped. Both children and adults with only iris coloboma will probably have fairly good vision.

What is the meaning of the word coloboma?

A coloboma describes conditions where normal tissue in or around the eye is missing at birth. Coloboma comes from the Greek word that means “curtailed.”. The eye develops quickly during a fetus’ first three months of growth.

Is it possible for coloboma to happen by chance?

There are no known strong links between environmental exposures and isolated coloboma. It is always possible that coloboma happens strictly by chance. In summary, there is little data to presently say why coloboma happened to a person in a family where no one else is affected. How does uveal coloboma happen?

When does a fetus develop a coloboma or space?

The eye develops quickly during a fetus’ first three months of growth. A gap, known as the choroidal fissure, appears at the bottom of the stalks that eventually forms the eye. This fissure generally closes by the seventh week of pregnancy. If it does not close, a coloboma or space forms. A coloboma can affect one or both eyes.

Where does coloboma appear in the human eye?

They may appear as notches or gaps in one of several parts of the eye, including the colored part of the eye called the iris; the retina, which is the specialized light-sensitive tissue that lines the back of the eye; the blood vessel layer under the retina called the choroid; or the optic nerves, which carry information from the eyes to the brain.