Is clindamycin safe in second trimester?

Is clindamycin safe in second trimester?

Clindamycin Pregnancy Warnings The results of a study have suggested that early second trimester treatment of bacterial vaginosis and abnormal vaginal flora with oral clindamycin may reduce the incidence of preterm delivery and late miscarriage (n=485).

What happens if you take clindamycin while pregnant?

It is unlikely that using clindamycin increases the chance of birth defects. Two human studies and several animal studies have not shown an increased chance of birth defects. One study reported a slightly higher chance of birth defects among 380 women who filled prescriptions for clindamycin in their first trimester.

Can clindamycin cause birth defects?

What pregnancy category is clindamycin?

Relative Risk of Human Teratogenic Risk Associated with Antibiotic Use in Pregnancy and Lactation

Antibiotic Teratogenicity risk/data available FDA Pregnancy Category
Clindamycin (Cleocin) Undetermined/limited B
Doxycycline (Vibramycin) Unlikely/fair D
Gentamicin Undetermined/limited C
Levofloxacin (Levaquin) Unlikely/fair C

Is clindamycin contraindicated in pregnancy?

In clinical trials with pregnant women, the systemic administration of clindamycin during the second and third trimesters, has not been associated with an increased frequency of congenital abnormalities. Clindamycin should be used during the first trimester of pregnancy only if clearly needed.

Does clindamycin cross the placenta?

Clindamycin was shown to readily cross the placenta in three term pregnant patients.

Is it safe to give clindamycin to pregnant women?

Animal reproduction studies with clindamycin have not shown risk to the fetus. In clinical trials with pregnant women, clindamycin given during the 2nd and 3rd trimesters has not been associated with an increased frequency of birth defects.

When is the best time to take clindamycin?

In clinical trials with pregnant women, clindamycin given during the 2nd and 3rd trimesters has not been associated with an increased frequency of birth defects. If medically indicated, clindamycin can be used during pregnancy. Clindamycin enters breast milk. Use during breastfeeding is not recommended.

Are there any side effects to taking clindamycin?

Clindamycin has been associated with C. difficile –associated diarrhea in up to 10% of patients regardless of route, including topical. Hypersensitivity reactions may occur. If not swallowed with water, clindamycin may cause esophagitis. Dose adjustments are not required for renal failure.

When to use clindamycin instead of penicillin?

-In the treatment of anaerobic infections, parenteral clindamycin should be used initially and then patients changed to oral therapy when clinically appropriate. -Clindamycin should be reserved for penicillin-allergic patients or other patients for whom a penicillin is not appropriate.

Is it safe to take clindamycin during pregnancy?

AU TGA pregnancy category: A. US FDA pregnancy category: B. Comments: Clindamycin solution for injection contains benzyl alcohol as a preservative, which can cross the placenta and is associated with the potentially fatal “gasping syndrome” in pediatric patients.

Is there a link between clindamycin and birth defects?

Two human studies and several animal studies have suggested that taking clindamycin would not increase the chance of birth defects. One study looking at prescription records reported a slightly higher chance for birth defects among 380 women who filled a prescription for clindamycin in their first trimester. However, this study cannot

In addition, a study on 249 pregnant women with vaginosis (high levels of bacteria in the vagina) who were treated with clindamycin in their second trimester reported that treatment appeared to lower the chance of a late miscarriage (between 14 and 20 weeks) and preterm birth (less than 37 weeks).

Based on a small number of women given clindamycin orally (by mouth) or intravenously (I.V.), the amount of clindamycin that is found in breast milk is small. Clindamycin might cause some gastrointestinal (GI) effects in a breastfeeding baby that would be similar to those seen in adults (e.g. nausea, diarrhea, stomach pain, vomiting,