How much is too much flecainide?
Your doctor may increase your dose by 50 mg taken twice per day every 4 days until the drug is effective. Most people don’t need doses higher than 150 mg taken every 12 hours. The maximum dose is 400 mg per day.
What is flecainide acetate 100mg?
It is used to restore normal heart rhythm and maintain a regular, steady heartbeat. It is also used to prevent certain types of irregular heartbeat from returning (such as atrial fibrillation). Flecainide is known as an anti-arrhythmic drug.
What is the normal level of flecainide toxicity?
Her wide complex tachycardia on admission was ultimately attributed to flecainide toxicity in setting of AKI. Six days after presentation, it was found that her flecainide level was in the toxic range at 2.02 ug/mL (normal range: 0.20-1.00 ug/mL, toxic>1.50 ug/mL).
How much flecainide should I take for atrial fibrillation?
The most commonly used doses are 100 to 150 mg bid. 8 Flecainide is usually initiated at 100 mg bid, though a minority of patients will respond to doses as low as 50 mg BID. The dose may be escalated based on QRS duration prolongation of less than 50% over baseline after 4 days of administration. Concomitant Therapy With Beta-Blocking Agents
How often should I increase my flecainide maintenance dose?
Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Most patients with SUSTAINED VT do not require more than 150 mg every 12 hours (300 mg/day), and the maximum dose recommended is 400 mg/day.
What was the past medical history of flecainide?
Past medical history was notable for paroxysmal atrial fibrillation for which she was on flecainide. At the nursing facility the patient was noted to be obtunded, whereas at baseline she was reportedly alert and oriented. On presentation to the Emergency Department EKG demonstrated wide-complex tachycardia.
What kind of mortality is associated with flecainide?
The Cardiac Arrhythmia Suppression Trial (CAST) revealed significantly higher mortality associated with flecainide in patients with a recent history (more than six days but less than two years prior to study) of myocardial infarction (MI) and non-life-threatening ventricular ectopy relative to placebo (5.1% versus 2.3%).
Are there any long term side effects of flecainide?
Flecainide may exacerbate myasthenia gravis. At least 6 cases of flecainide-induced peripheral neuropathy (sensory loss) have been reported and it appears to develop after prolonged use (2 to 10 years).
Is it safe to take flecainide for atrial fibrillation?
Not recommended for chronic atrial fibrillation. 10.5% incidence of ventricular tachycardia/fibrillation in patients treated for chronic atrial fibrillation. Proarrhythmic effects with flecainide for atrial fibrillation/flutter: Increased risk of PVCs, ventricular tachycardia, ventricular fibrillation, and fatality.
Maintenance dose: May be increased in increments of 50 mg bid every 4 days until efficacy is achieved. Most patients with SUSTAINED VT do not require more than 150 mg every 12 hours (300 mg/day), and the maximum dose recommended is 400 mg/day.