How it is manufactured influenza vaccine?
The fluid containing virus is harvested from the eggs. For inactivated influenza vaccines (i.e., flu shots), the vaccine viruses are then inactivated (killed), and the virus antigen is purified. The manufacturing process continues with quality testing, filling and distribution.
Who is manufacturing the flu vaccine?
Influenza Vaccine for the 2020-2021 Season
|Manufacturer||Total Number of Lots Released by FDA|
|Fluad Quadrivalent Seqirus, Inc.||19|
|Fluarix Quadrivalent GlaxoSmithKline Biologicals||47|
|Flublok Quadrivalent Protein Sciences Corporation||94|
|Flucelvax Quadrivalent Seqirus, Inc.||65|
How are vaccines manufactured?
Several vaccines are made by taking toxins and inactivating them with a chemical (the toxin, once inactivated, is called a toxoid). By inactivating the toxin, it no longer causes disease. The diphtheria, tetanus and pertussis vaccines are made this way.
Where do the flu vaccines come from?
The inactivated influenza viruses present in vaccines are usually grown inside fertilized chicken eggs, where the virus replicates. Then, the manufacturers separate the virus from the egg and include it in the vaccine. As a result, the finished vaccine may contain small amounts of egg proteins.
When did the FDA approve the flu vaccine?
A flu vaccine containing an adjuvant was approved by the US Food and Drug Administration (FDA) in November 2015, for use by adults aged 65 years of age and older. The vaccine is marketed as Fluad in the US and was first available in the 2016–2017 flu season.
Who made the first vaccine?
Edward Jenner is considered the founder of vaccinology in the West in 1796, after he inoculated a 13 year-old-boy with vaccinia virus (cowpox), and demonstrated immunity to smallpox. In 1798, the first smallpox vaccine was developed.