Does fragile X syndrome affect the brain?
Fragile X syndrome is one of the most common inherited causes of intellectual disability, which is a term used when there are limits to a person’s ability to learn at an expected level, and function in daily life. Fragile X syndrome is caused by a change in the genetic material that mostly affects brain cells.
Is Fragile X Syndrome a psychological disorder?
Fragile X syndrome is the leading inherited form of mental retardation, and second only to Down’s syndrome as a cause of mental retardation attributable to an identifiable genetic abnormality.
Is Fragile X syndrome mental retardation?
The Fragile X (FRAXA) syndrome is the most common cause of familial (monogenic) mental retardation and is widespread in human populations. This syndrome is characterised by an unusual mode of transmission for an X-linked disease.
How does fragile X syndrome affect a person?
There are some physical features associated with Fragile X syndrome, but they may be subtle or not present: About one-third of females with Fragile X syndrome have a significant intellectual disability. Others may have moderate or mild learning disabilities, emotional/mental health issues, general anxiety, and/or social anxiety.
How is fragile X syndrome related to FMR1?
The abnormally expanded CGG segment inactivates (silences) the FMR1 gene, which prevents the gene from producing a protein called fragile X mental retardation protein. Loss of this protein leads to the signs and symptoms of fragile X syndrome.
Can a female have fragile X syndrome ( NICHD )?
If the mutation is in most of the body’s cells, the person will probably have symptoms of Fragile X syndrome. If the mutation is in only some of the cells, the person might not have any symptoms at all or only mild symptoms. Being female. Females have two X chromosomes (XX), while males have only one.
What kind of protein does fragile X make?
The gene normally makes a protein called Fragile X Mental Retardation Protein, or FMRP. This protein is important for creating and maintaining connections between cells in the brain and nervous system.
What is the life expectancy of Fragile X syndrome?
Life expectancy for people with fragile X syndrome is generally normal. Many affected people participate in an active lifestyle and have good health.
What are the main causes of Fragile X syndrome?
Fragile X syndrome is a genetic disorder caused by a change to one of the genes on the X chromosome . It is the most common inherited cause of intellectual disability and the most common single gene cause of autism.
How does fragile X syndrome affect the body?
Fragile X syndrome is a genetic disorder that affects a person’s development, especially that person’s behavior and ability to learn. In addition, Fragile X can affect communication skills, physical appearance, and sensitivity to noise, light, or similar information.
Is fragile X syndrome the same as autism?
Fragile X syndrome is a leading genetic cause of autism. About one in three people with the syndrome also has autism. But even those who do not have autism often share certain autistic traits, such as avoidance of eye contact and difficulties in social situations.