Does Fragile X occur more in males or females?
The fragile X syndrome affects about 1 in 4,000 males and 1 in 6,000 to 8,000 females in the USA; that is, it affects about twice as many males as it does females. However, about four times as many females appear to be carriers of the altered gene as do males (1:250 females and 1:1000 males).
Does Fragile X only affect males?
Both males and females with fragile X syndrome are fertile. Girls with fragile X syndrome are at risk for having children who also have fragile X syndrome. Boys with fragile X syndrome are premutation carriers, even though they themselves have the full mutation.
Why does Fragile X syndrome affect males more than females?
Symptoms of Fragile-X syndrome are more severe in males compared with females. Because females have two X chromosomes, an inherited damaged FMR1 gene can be compensated for by an inherited healthy FMR1 gene. Unlike females, males only have one X chromosome, so an inherited damaged copy is their only copy.
How many people are diagnosed with Fragile X syndrome?
. 1 FXS affects both males and females. Females often have milder symptoms than males. 2 The exact number of people who have FXS is unknown, but a review of research studies estimated that about 1 in 7,000 males and about 1 in 11,000 females have been diagnosed with FXS. 3
How is fragile X syndrome related to Down syndrome?
Fragile X syndrome affects 1 in 1500 of the population and is, after Down syndrome, the second most common chromosomal defect associated with learning impairment. Fragile X syndrome is so named because the tip of the X chromosome is susceptible to breakage.
Can a person with Fragile X syndrome have a full time job?
Almost half of women with FXS had full-time jobs, compared to 2 in 10 men. People with a fragile X premutation do not have fragile X syndrome but might have another fragile X-associated disorder. Some people with fragile X premutations have noticeable symptoms, and others do not.
What are the treatment options for Fragile X syndrome?
Fragile X syndrome. These interventions may include special education, speech therapy, physical therapy, or behavioral therapy. Medications may be used to treat associated seizures, mood problems, aggressive behavior, or ADHD. Fragile X syndrome is estimated to occur in 1.4 in 10,000 males and 0.9 in 10,000 females.
What is the life expectancy of Fragile X syndrome?
Life expectancy for people with fragile X syndrome is generally normal. Many affected people participate in an active lifestyle and have good health.
What are the main causes of Fragile X syndrome?
Fragile X syndrome is a genetic disorder caused by a change to one of the genes on the X chromosome . It is the most common inherited cause of intellectual disability and the most common single gene cause of autism.
What are the specific symptoms of Fragile X syndrome?
Fragile X Syndrome Symptoms. Though the severity of symptoms differs between men and women, some common fragile X syndrome symptoms are hyperactivity, impulsivity, anxiety, mood swings, tremors, and poor coordination.
What is the prognosis for Fragile X?
According to research, around 44% of women and 10% of men having fragile X syndrome are able to attain a high level of independence as adults. The life expectancy of a patient with fragile X syndrome is thought to be the same as any other normal person. The prognosis also depends on the degree of the symptoms of this condition.